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. 2006 Nov;128(5):593–604. doi: 10.1085/jgp.200609648

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Action of diC₈ PI(4,5)P₂ on the gating of HCN2. (A) Dose–response curve for shift in V_1/2 (ΔV_1/2) as a function of concentration of diC₈ PI(4,5)P₂. Data fit with the Hill equation. (B) Time constants (τ) of HCN2 current activation (left) and deactivation (right) in absence (squares, solid line) and presence (circles, dashed line) of 25 μM diC₈ PI(4,5)P₂. The difference between the time constants of activation at −135 mV before (0.731 ± 0.079 s) and after (1.28 ± 0.22 s) diC₈ PI(4,5)P₂ application were statistically significant (*, P < 0.02, t test). The difference between the time constants of deactivation at −40 mV before (67.6 ± 5.0 ms) and after (136 ± 13 ms) diC₈ PI(4,5)P₂ application were also statistically significant (*, P < 0.001, t test).