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. 2006 Nov;128(5):593–604. doi: 10.1085/jgp.200609648

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Copyright © 2006, The Rockefeller University Press

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Figure 6. — Application of MgATP to inside-out patches shifts HCN2 activation to more positive voltages. (A) Time course of V_1/2 of HCN2 in a single inside-out patch experiment showing rundown and response to MgATP. Experiment performed in FV solution to inhibit endogenous phosphatase activity. (B) Time course of average V_1/2 shift after bath application of MgATP in absence (squares) or presence (inverted triangles) of 15 μM wortmannin to block PI kinases. For data in response to MgATP alone, the single exponential fit yielded values for the steady-state shift in V_1/2 of +9.5 mV and a t_1/2 of 3.8 min.