Figure 3.

The Ca²⁺ channel β subunit, but not the α_1C N and C termini, are required for Gem- or Rem2-mediated effects. (A and B) Normalized I _Ba for the indicated combinations of α_1C (WT), the N-terminal truncation (ΔN), or the C-terminal truncation (ΔC), with or with Gem or Rem2, as indicated. All combinations were coexpressed with β3 and α₂δ. Scaled exemplar current for each pair with (black) or without (gray) Gem or Rem2 are shown on right. n = 5–9. Bars: 50 ms (A) and 1 s (B). (C and D) Normalized I _Ba for the indicated combinations of ΔC and α₂δ with or without β3 and Gem or Rem2, as indicated. For the pair without β3, scaled exemplar currents with (black) or without (gray) Gem or Rem2 are shown on right. n = 5. Scale bars as above.