Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Nov;128(5):535–545. doi: 10.1085/jgp.200609516

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Modification of CFTR by intracellular MTSES. (A) Example leak-subtracted macroscopic I-V relationships in inside-out membrane patches with symmetrical 154 mM Cl⁻ solutions, after maximal channel activation. Currents were recorded at various times before (time zero) and after application of 200 μM MTSES to the intracellular solution. Time after application of MTSES, in minutes, is shown alongside each I-V relationship. (B) MTSES-induced changes in I-V shape. Data from the same patches as in A, recorded before (control) and 6 min after addition of MTSES, are scaled to show the development of outward rectification in R303C but not wild type. (C) Time course of current rundown for these two example patches; current at +80 mV (I ₊₈₀) and −80 mV (I ₋₈₀) was monitored continuously after application of MTSES. (D) Lack of rundown over the same timescale on addition of vehicle alone in wild type. (E) Change in rectification ratio with time after addition of MTSES for the two patches used in A–C.