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Evidence for cation–π energetics in TEA block. (A and B) Reversible TEA inhibition for Phe and Cha currents at 50 mV. (C) TEA inhibition plots for Shaker channels containing the indicated residue at position 449. Curves are standard binding isotherms fitted to the data. Increased fluorination monotonically increases the dissociation constant K i (Table I). Cha, which is devoid of aromatic character, renders the channel nearly insensitive to TEA.
