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. 2006 Dec;128(6):659–669. doi: 10.1085/jgp.200609650

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Neuronally evoked increases in endfoot [Ca²⁺]_i involve Ca²⁺ release from an intracellular Ca²⁺ store, likely through activation of InsP₃R. (A) EFS was used to induce neuronal activity, allowing for the generation of multiple consistent increases in endfoot [Ca²⁺]_i. (B) Representative traces illustrating that EFS-induced increases in endfoot [Ca²⁺]_i were significantly decreased after a 20-min incubation with 10 μM of the InsP₃R antagonist xestospongin C. (C) Mean data showing the effect of RYR, InsP₃R, and phospholipase C inhibition on the generation of EFS-induced [Ca²⁺]_i increases. Drug-treated responses are compared with the mean time-matched control response. (D) Representative traces illustrating that EFS-induced increases in endfoot [Ca²⁺]_i were significantly decreased after a 20-min incubation with 30 μM of the SERCA pump inhibitor CPA to deplete the internal Ca²⁺ store. (E) Mean data showing the peak [Ca²⁺]_i increase elicited under control conditions and after incubation with CPA. Responses generated in the presence of CPA are compared with the mean time-matched control response. Error bars indicate mean ± SEM. *, P < 0.05; **, P < 0.0001.