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. 2006 Dec;128(6):659–669. doi: 10.1085/jgp.200609650

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Astrocytic endfeet act as individual “vasoregulatory units” and modulate arteriolar diameter through activation of Ca²⁺-sensitive signaling mechanisms driven by Ca²⁺ release through InsP₃R. (A) Photorelease of InsP₃ in a single endfoot (arrow) abutting an arteriole in a rat cortical brain slice generated a rapid vasodilation in the region of the arteriole directly apposed to the endfoot. This dilation was restricted to an ∼30-μm length of the vessel. (B) Trace shows the diameter of the arteriole examined in A as a function of time. Note the rapid dilation of the arteriole in response to liberation of InsP₃ in the endfoot. (C) Averaged data showing the diameter of arterioles adjacent to endfeet before and after photorelease of InsP₃ in the endfeet. Error bars indicate mean ± SEM. *, P < 0.05.