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. 2006 Dec;128(6):731–744. doi: 10.1085/jgp.200609596

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — The mβ1 subunit promotes BK channel activation in high Ca²⁺ and reduces channel activation in low Ca²⁺. (A) Left, families of BK/α currents evoked by 40-ms depolarizations (20-mV steps over the indicated range) in 7 μM Ca²⁺. Right, normalized G-V relationships (mean ± SEM) of BK/α at indicated Ca²⁺ (n = 12–44). (B) Left, families of BK/α+β1 currents evoked by 40-ms depolarizations (20-mV steps over the indicated range) in 7 μM Ca²⁺. Right, normalized G-V relationships (mean ± SEM) of BK/α+β1 at indicated Ca²⁺ (n = 7–39). (C) V_1/2-Ca²⁺ relationships (mean ± SEM) for BK/α (open symbols) and BK/α+β1 channels (closed symbols). (D) Q-Ca²⁺ relationships (mean ± SEM) for BK/α (open symbols) and BK/α+β1 channels (closed symbols).