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. 2006 Dec;128(6):731–744. doi: 10.1085/jgp.200609596

Figure 8.

Figure 8.

Intracellular domain deletions impair β1's ability to reduce L0 and shift VhO. (A) Examples of single channel currents of BK/F315Y+β1ΔN11. (B) Representative logPO-V relations of BK/α+β1ΔN11 where the limiting slope were fitted to Eq. 4 to estimate zL. zL values indicated in the figure represent mean ± SEM (n = 8). (C) Best fits to the HA model (held zL = 0.24 e0, zJ = 0–0.58 e0, yielded L0 = 5.5e−3, zJ = 0.58 e0, VhC = +69 mV, and VhO = +15 mV). (D) Examples of single channel currents of BK/F315Y+β1ΔC11. (E) Representative logPO-V relations of BK/α+β1ΔC11 where the limiting slope was fitted to Eq. 4 to estimate zL. zL value indicated in the figure represents mean ± SEM (n = 5). (F) Best fits to the HA model (held zL = 0.24 e0, zJ = 0–0.58 e0, yielded L0 = 8 e−3, zJ = 0.58 e0, VhC = +103 mV and VhO = +43 mV). (G) Examples of single channel currents of BK/F315Y+β1ΔN10C11. (H) Representative logPO-V relations of BK/F315Y+β1ΔN10C11 where the limiting slope was fitted to Eq. 4 to estimate zL. zL values indicated in the figure represent mean ± SEM (n = 8). (I) Best fits to the HA model (held zL = 0.13 e0, zJ = 0–0.58 e0, yielded L0 = 1.3 e−2, zJ = 0.58 e0, VhC = +98 mV, and VhO = +29 mV).