TABLE I.

Definitions of Gating Parameters (Horrigan and Aldrich, 2002)

L	C-O equilibrium constant (unliganded channel, resting voltage sensors).
		L = L0exp(zLV/kT)
		L0 and zL are the zero voltage value of L and its partial charge,     respectively.
J	R-A equilibrium constant (closed, unliganded channel)
		J = J0 exp(−zJV/kT)
		J0 and zJ are the zero voltage value of J and its partial charge,     respectively.
D	Allosteric factor describing interaction between channel opening     and voltage sensor activation
		D = exp [−zJ(VhO − VhC)/kT]
		VhC and VhO are half-activating voltage of QC and QO, respectively.
		QC and QO are steady-state gating charge distribution for closed or     open channels.