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. 2007 Mar;129(3):221–231. doi: 10.1085/jgp.200609658

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Quantal GABA and ATP release in rat β cells monitored by overexpression of the ionotropic membrane receptors GABA_A and P₂X₂. Examples of GABA- (A) and ATP-activated (B) TICs recorded from β cells infected with GABA_A and P₂X₂ receptors, respectively. Cells were held at −70 mV and exocytosis elicited by intracellular application of 2 μM free Ca²⁺. The cartoons above the current traces illustrate schematically the protocols used. (C) Samples of GABA (transient outward currents; top trace) and ATP release events (transient inward currents; bottom trace) triggered by 500-ms depolarizations from −70 to 0 mV. The latency between the beginning of the depolarizing pulse and the onset of the first exocytotic event during the pulse (L₁) was measured. (D) Cumulative frequency of the first latencies of GABA release (black squares) and ATP release (open circles).