TABLE I.

Kinetic Parameters Estimated for the Dual Allosteric Model for Wild-type BK Channels

Parameter	Fit A	Fit B
J0	0.05	0.07
zJ (e0)	0.56	0.56
KD (μM)	21.8	21.8
L0	2.0 × 10−7	3.0 × 10−7
zL(e0)	0.21	0.21
C	8	10
D	40	40
E	6	3

Value of z_J was based on estimates presented in Horrigan and Aldrich (2002) and Ma et al. (2006). C and E were not well determined by the current data and were set to the above values to be consistent with estimates of Horrigan and Aldrich (2002), Ma et al. (2006), and Wang et al. (2006).