Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Apr;129(4):345–350. doi: 10.1085/jgp.200709757

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Properties of D78A and E79A. (A) Faster rate of desensitization compared with wild-type (WT) channels. Channels are opened by a step to pH 6.0 from pH 8.0. (B) Currents from the indicated channels evoked by a step to pH 6.0 from a bath solution of the indicated pH. Wild-type and D78A channels are half desensitized near pH 7.2/7.1, whereas E79A channels are half desensitized at pH 8. (C) Steady-state desensitization curves (open symbols) and activation curves (closed symbols) for the indicated channels. E79A channels have identical activation curves to wild type, but greatly shifted desensitization. D78A channels are little changed from wild type for either curve. Desensitization curves plot the normalized peak currents against the conditioning pH, as in B. Activation curves plot normalized peak current against the test pH (raw data not depicted).