TABLE I.

Desensitization Time Constants of ASIC3 Mutants

Mutant	τ (ms)
WT	385 ± 8 (27)
E63A	698 ± 31 (5)
H73A	371 ± 6 (6)
T75A	178 ± 7 (4)
L77A	53 ± 5 (14)
D78A	77 ± 3 (17)
D78C	173 ± 6 (17)
D78E	401 ± 16 (15)
D78N	39 ± 2 (12)
D78R	22 ± 2 (11)
E79A	97 ± 3 (31)
E79C	119 ± 4 (16)
E79D	36 ± 1 (9)
E79P	18 ± 1 (9)
E79Q	153 ± 6 (8)
R80A	35 ± 1 (9)
R80C	175 ± 9 (5)
R80E	41 ± 1 (3)
E81A	140 ± 6 (14)
S82A	1192 ± 166 (15)
R99A	394 ± 17 (3)
R102A	371 ± 8 (3)
D107A	338 ± 10 (4)
E432A	412 ± 12 (11)
E435A	395 ± 17 (8)
D439A	*
D78A/E79A	22 ± 1 (13)

Results are given as mean ± SEM (n). * indicates D439A mutants did not express.