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. 2007 Jun;129(6):493–508. doi: 10.1085/jgp.200609604

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Glucose elicits similar changes in the cytosolic Ca²⁺ concentration in healthy and diabetic rats. (A) Ratio images of Fura PE3-AM bulk-loaded Wistar (left, also see Video 1) and GK (right, also see Video 3) rat islets before (top images, t = 0 s) and after (bottom images, t = 1,800 s) application of 20 mM glucose (glc). (B) Mean pixel intensity data of ROI1 (black traces) and ROI2 (gray trace) shown in A. Dotted lines indicate the response amplitude.