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. 2007 Jun;129(6):493–508. doi: 10.1085/jgp.200609604

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Functional vesicle pool sizes and RP refilling kinetics are not changed in β cells of diabetic rats. (A, i) Dual-pulse protocols used to estimate the maximal size of RP and IRP in β cells. (Top panels) Inward I_Na,Ca currents (peak I_Na transients truncated) and ΣΔC_m elicited by depolarizations from −89 to 1 mV (bottom panels). (ii) The maximal RP (left) and IRP (right) size estimates in Wistar and GK rat β cells showed no difference. n.s., unpaired t test. (B) The time course of RP recovery after depletion is also similar in Wistar and GK rat β cells. The ratio of the summed C_m responses (S ₂/S ₁, see text) in response to two successive dual-pulse stimulations as a function of the delay time between the double pulses is shown for Wistar (closed symbols) and GK rat β cells (open symbols) (data binned for delay times, n.s., unpaired t test). Interpulse intervals have been randomized and at least 30 s between two dual-pulse pairs was allowed to ensure complete recovery of RP. The combined data of Wistar and GK β cells were fitted by a single exponential function (solid line: τ = 5.6 s, y intercept S₂/S₁ = 0.35).