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. 2007 Sep;130(3):257–268. doi: 10.1085/jgp.200609719

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Copyright © 2007, The Rockefeller University Press

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Figure 9. — A general kinetic model for gating in a voltage-gated ion channel. C₀ corresponds to the fully deactivated state, with all four S4 segments in the resting position. C₁, C₂, C₃, and C₄ correspond to the states where voltage sensors from domains I, II, III, and IV are activated. The numbers in the index refers to voltage sensors that are in activated position. C₁₂₃₄ corresponds to the fully activated state and the open channel form, with all the S4 segments in the activated position.