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. 2007 Oct;130(4):415–425. doi: 10.1085/jgp.200709771

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Molecular modeling of the DCS and EEEE loci in the channel pore. (A) Sequence alignment of the P loops of Ca_V1.2, Ca_V2.1, and Ca_V2.3 HVA channels and Ca_V3.1, Ca_V3.2, and Ca_V3.3 LVA channels. * and # boxes, position of EEEE and DCS loci in each domain of the Ca_Vα subunit. Note the nonconservation of the DCS charged amino acids. Arrows underline the non-DCS amino acids mutated in Fig S4: S1611 and G1323 in Ca_V2.3. (B) A molecular model of the C-terminal end of the four P loops of Ca_V2.3 channel. Left, radial projection of the channel with one of the domains omitted for the clearness of the picture. Right, schematic representation of the EEEE and DCS loci of Ca_V2.3 channel. Ribbons represent the backbone of the peptidic chains. Ca²⁺ ions are shown as magenta balls. Negatively charged side chains of the channel are shown by ball-and-stick representation (see Materials and methods for details).