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. 2007 Oct;130(4):415–425. doi: 10.1085/jgp.200709771

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — DCS locus controls the channel-specific cation selectivity profile. (A and B) A Ca_V2.3 channel with an engineered Ca_V2.1 DCS locus (Ca_V2.3(DEQN), square) displays AMFE and has an ICa/IBa ratio similar to Ca_V2.1. Conversely, a Ca2.1 channel with a Ca_V2.3 DCS locus (Ca_V2.1(TEQE), ▵) behaves like Ca_V2.3. (A) Current traces and (B) current–mole fraction curves. Dashed lines, current/mole fraction curves of parent channels, Ca_V2.3 and Ca_V2.1, determined in Fig. 1. (C) The current reversal potentials, recorded in 10 mM Ca²⁺ or 10 mM Ba²⁺ (left), and the Cd²⁺ block of Ba²⁺ current (right) for Ca_V2.3 (□) and Ca_V2.1(▿) channels are not changed by the mutations (Ca_V2.3(DEQN), ○; and Ca_V2.1(TEQE), ▵), suggesting the EEEE locus is not modified.