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. 2007 Oct;130(4):415–425. doi: 10.1085/jgp.200709771

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Mutations at the DCS locus modify selectivity profiles of LVA without changes in gating. (A) Schematic representation of the amino acids present at the Ca_V3.1, Ca_V3.2, and Ca_V3.3 DCS loci. (B) Current–mole fraction curves obtained for the WT (▵) and two mutant Ca_V3.2 LVA channels mimicking the DCS loci of Ca_V3.1 (Ca_V3.2(DKDG), □) and Ca_V3.3 (Ca_V3.2(EVNG), ○). Ba/Ca current ratio was significantly changed for the Ca_V3.2(DKDG) mutant that also displayed a small AMFE as opposed to WT Ca_V3.2. (C) Voltage-dependent parameters of the current–voltage curves and inactivation curves of the Ca_V3.2, Ca_V3.2(EVNG), and Ca_V3.2(DKDG) LVA channels. These two mutations were without noticeable effects on these parameters.