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. 2007 Dec;130(6):631–645. doi: 10.1085/jgp.200709859

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Distinct patterns of InsP₃R channel gating in each of the three modes as revealed by burst filtering. The current records were obtained in saturating 10 μM InsP₃ and [Ca²⁺]_i as tabulated. Each section consists of a set of three traces of the same single channel current record: (top) unprocessed current trace, (middle) idealized current trace generated from current record using Qub software, and (bottom) idealized current trace after burst analysis. (A) InsP₃R gating in high-P _o, H, mode in which the channel opens mainly in bursts whose gating behavior is substantially affected by burst analysis. (B) InsP₃R gating in intermediate-P _o, I, mode with rapid opening and closing kinetics that is largely unaffected by burst analysis. (C) Channel gating in low-P _o, L, mode with brief openings separated by very long closed durations.