Figure 7.

InsP₃R channel gating parameters in various [Ca²⁺]_i and [InsP₃] evaluated using experiment-based statistics (see Appendix). The same channel gating parameters are plotted in the same panels with the same symbols and color code as in Fig. 3: (A) channel open probability P _o; (B) channel open probability in each of the three gating modes (C) relative prevalence π ^M for the three gating modes; (D) relative frequency f ^M of the gating modes; (E) mean overall channel opening 〈t _o〉 and closing 〈t _c〉 duration; (F–I) mean durations of channel opening closing bursts and burst-terminating gaps respectively, for the gating modes; (J) mean duration 〈τ ^M〉 of the gating modes. Error bars in (A, B, and E–J) indicate standard errors of the mean evaluated using experiment-based statistics (see Appendix). Parameters marked with asterisks are those observed in suboptimal ligand concentrations that are statistically significantly different from those observed in optimal [Ca²⁺]_i (1 μM) and saturated [InsP₃] (10 μM).