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. 2007 Dec;130(6):631–645. doi: 10.1085/jgp.200709859

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Copyright © 2007, The Rockefeller University Press

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Figure 8. — Schematic diagram showing the simplest completely-interconnected Markov kinetic model for three distinct gating modes. Each of the three modes (L, H, and I modes) consists of one closed (C_M) and one open (O_M) kinetic states, with state transition rates for channel opening (k _oM) and closing (k _cM) as tabulated. The three modes are completely interconnected through the closed kinetic states (C_H, C_I, and C_L) with six mode transition rates (k _HL, k _HI, k _IL, k _IH, k _LI, and k _LH). Through stochastic simulation, these kinetic rates were used to generate virtual channel current records, which in turn were used to check the accuracy of the modal analysis algorithm.