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. 2007 Nov;130(5):465–478. doi: 10.1085/jgp.200709843

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Effect of voltage on the inactivation gating. (A) Macroscopic currents elicited in response to pH jump from 8.0 to 3.0 and recorded at various membrane potentials. (B) The time constant of inactivation, measured by fitting a single exponential to the decay phase of the macroscopic, was plotted as a function of voltage. KcsA inactivates faster when the membrane is held at hyperpolarizing potentials. (Inset) Shows normalized time constants from three patches.