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. 2007 Nov;130(5):465–478. doi: 10.1085/jgp.200709843

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Copyright © 2007, The Rockefeller University Press

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Figure 7. — Recovery from inactivation. Currents were elicited by a double pH pulse protocol with a variable interpulse duration at pH 8.0 to monitor the recovery time course of KcsA. The membrane was held at either +100 mV (A) or −100 mV (B). The amplitude of the current in response to the second pulse starts to increase progressively as the interpulse increases above 500 ms. (C) Fractional recovery, as measured by (I/I _max), from four patches was plotted as a function of the interpulse interval and fitted to a single exponential. Recovery of KcsA from inactivation is modulated by voltage and occurs approximately threefold faster at +100 mV than at −100 mV.