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Inhibition of prothrombinase activity by sPLA2. Factor Xa was preincubated with synthetic (▾) or recombinant (▴) sPLA2 (2.5 μM, final concentration). After 15 min, a mixture of factor V, prothrombin, and phospholipid vesicles was added, and prothrombin activation was measured. At different times, thrombin amidolytic activity was determined and quantitated by using an appropriate standard curve. The data represent the average ± SD of three experiments.
