Figure 5.

Effects of hyperoxia on stretch-induced JNK activation of airway epithelium in JNK knockout mice. Phospho-JNK-positive cells were quantified as the average number of epithelial cells with dark brown DAB signals per bronchiole, which were counted from 10 randomly chosen bronchioles of each section (n = 5 per group). *p < 0.05 versus control, non-ventilated mice; †p < 0.05 versus all other groups. DAB, diaminobenzidine; JNK, c-Jun NH₂-terminal kinase; RA, room air; V_T, tidal volume; WT, wild-type mice.