Table 4.
Hemodynamic parameters in study groups
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | p value | |
| Heart rate (beats per minute) | ||||||
| Bolus group | 107 ± 20 | 93 ± 20 | 85 ± 20 | 78 ± 22 | 86 ± 21 | 0.93 |
| Infusion group | 100 ± 21 | 95 ± 19 | 87 ± 23 | 86 ± 22 | 83 ± 15 | |
| Mean arterial pressure (mm Hg) | ||||||
| Bolus group | 62 ± 7.5 | 75 ± 12 | 79 ± 13 | 85 ± 15 | 87 ± 15 | 0.06 |
| Infusion group | 65 ± 7.9 | 72 ± 9.4 | 72 ± 12 | 75 ± 13 | 79 ± 19 | |
| Cardiac index (liters/minute per m2) | ||||||
| Bolus group | 3.8 ± 1.7 | 3.5 ± 1.1 | 3.5 ± 0.9 | 3.4 ± 1.0 | 3.4 ± 0.7 | 0.52 |
| Infusion group | 3.6 ± 1.5 | 3.9 ± 1.3 | 3.5 ± 1.1 | 3.6 ± 1.3 | 3.8 ± 1.5 | |
| SvO2 (percentage) | ||||||
| Bolus group | 61 ± 7.6 | 67 ± 7.2 | 69 ± 7.3 | 70 ± 7.6 | 69 ± 7.0 | 0.50 |
| Infusion group | 64 ± 12 | 65 ± 10 | 63 ± 11 | 66 ± 13 | 70 ± 13 | |
| SVR (dyn·s/cm5) | ||||||
| Bolus group | 623 ± 221 | 770 ± 323 | 861 ± 249 | 999 ± 334 | 1,061 ± 200 | |
| Infusion group | 731 ± 254 | 705 ± 248 | 818 ± 274 | 836 ± 332 | 832 ± 214 | |
| Shock reversal, n (percentage) | ||||||
| Bolus group | 0/24 (0%) | 3/24 (13%) | 14/24 (58%) | 18/24 (75%) | 20/24 (83%) | 0.48 |
| Infusion group | 0/24 (0%) | 5/24 (21%) | 12/24 (50%) | 14/24 (58%) | 15/24 (63%) |
P values represent difference between the study groups (analysis of variance and log-rank test). SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance.