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Norepinephrine (NE) released in the PFC activates different intracellular signaling pathways through distinct adrenoceptors with varying affinities for NE. PFC cognitive function is enhanced by moderate levels of NE engaging post-synaptic α2A receptors with high affinity for NE, while high levels of NE impair PFC cognitive function by engaging α1 and β1 receptors with lower affinity for NE. AC, adenylyl cyclase; LC, locus coeruleus; PLC, phospholipase C; DAG, diacylglycerol.
