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(A) Diagram depicting B cell development. Ig DHJH and VHDHJH gene rearrangements are indicated. Transcriptional regulators controlling distinct checkpoints during B-lineage maturation are shown. (B) Diagram depicting T-lineage development. TCR gene rearrangements are indicated. Notch signaling and transcriptional regulators controlling distinct checkpoints during T-lineage maturation are shown.
