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Values of Ki for ONC and its variants
| ONC |
Ki (μM)a |
|
|---|---|---|
| 5′-GMP | 5′-AMP | |
| Wild-type | (6.7 ± 0.5) × 102 | (3.7 ± 0.3) × 103 |
| T89K | (5.3 ± 0.2) × 102 | (2.0 ± 0.2) × 103 |
| T89R | (4.3 ± 0.6) × 102 | (2.4 ± 0.4) × 103 |
| T89N | (1.0 ± 0.1) × 103 | (1.2 ± 0.1) × 103 |
| E91A | (1.3 ± 0.3) × 103 | (3.2 ± 0.4) × 103 |
| T89N/E91A | (9.9 ± 0.7) × 102 | (5.9 ± 0.2) × 102 |
Values of Ki (±SE) are for inhibition of catalysis of 6-FAM–dArUdGdA–6-TAMRA cleavage in 0.10 M MES–NaOH buffer (pH 6.0) containing NaCl (0.10 M) at 23 ± 2 °C.
