Table 2.

Summary of binding data, cAMP responses, and insulin responses for Xenopus GLPs

Peptides	hGLP-1 (7-36)NH2	xenGLP-1A (1-32)	xenGLP-1A (1-37)	xenGLP-1B (1-30)	xenGLP-1B (1-32)	xenGLP-1C (1-30)
IC50 (nM)	4.4  ±  1.0	17.5  ±  4.7*	12.7  ±  4.3	1.1  ±  0.4†	2.9  ±  0.7	43.4  ±  10.5‡
EC50 cAMP (nM)	0.6  ±  0.2	8.6  ±  3.5§	2.0  ±  0.9	0.17  ±  0.02	1.1  ±  0.3	18.8  ±  0.4¶
Insulin (nM/50 min)	1,050  ±  170	850  ±  105	ND	1,300  ±  200	ND	950  ±  150

Data are presented as the mean ± SEM of at least three independent observations. ND, not done. 

^*P < 0.02 comparing hGLP-1 with xenGLP-1A(1–32). 

^†P < 0.02 to xenGLP-1B(1–30). 

^‡P < 0.004 to xenGLP-1C(1–30). 

^§P < 0.003 comparing hGLP-1 with xenGLP-1A(1–32). 

^¶P < 0.0001 to xenGLP-1C(1–30).