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. Author manuscript; available in PMC: 2008 Dec 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2007 Sep 16;225(3):267–277. doi: 10.1016/j.taap.2007.08.028

Figure 3. Time- and dose-dependent changes in biological pathways affected by WY-14,643 in mouse liver.

Figure 3

Significant genes from EDGE analysis (Figure 3) were used to identify enriched biological processes affected by WY-14,643 treatment. Supervised hierarchical clustering was used to organize treatments and strains (columns) and biological processes (rows). Processes that were down- (top half) and up- (bottom half) regulated were analyzed separately. Heat map shading reflects the significance (based on false discovery rate statistics, FDR) for a given pathway. The pathways are ordered within each category according to Gene Ontology hierarchy.