Figure 2.

Association of abstinence-induced craving with regional CBF changes. The five coronal slices (4 in top row; 1 in bottom row) show suprathreshold craving-correlated CBF changes in bilateral thalamus, bilateral nucleus accumbens, right insula, bilateral medial temporal cortex, left caudate/putamen, bilateral dorsolateral prefrontal cortex, anterior cingulate cortex, and the orbitofrontal cortex. An axial slice (bottom row) shows suprathreshold clusters in the amygdala and the hippocampus. Suprathreshold correlation clusters in the occipital cortex, midbrain, and the anterior cingulate were also shown in the sagittal slice (bottom row). The voxelwise statistical significance threshold is p < 0.005 (t >3.17, two tailed, uncorrected) and the color bar indicates the range of t values displayed.