Association of abstinence-induced global withdrawal scores with regional CBF changes. Significant correlations of CBF change with change in withdrawal symptoms were found in the right dorsolateral prefrontal cortex, caudate, right hippocampus, and the right medial temporal gyrus. The voxelwise statistical significance threshold is p < 0.005 (t >3.17, two tailed, uncorrected) and the color bar indicates the range of t values displayed.