Table 1.
Tumor profiles induced by wild-type PTA, 315YF, and 250YS mutant viruses
| Tumors | Nos. of mice
|
||
|---|---|---|---|
| PTA | 315YF | 250YS | |
| Fraction of mice with tumors(s) | 256/259 (99) | 257/332 (77) | 66/66 (100) |
| Mean age at necropsy in days | 108 | 301 | 138 |
| Epithelial tumors | |||
| Thymus | 227 (88) | 185 (56) | 45 (68)* |
| Skin: Hair follicle | 229 (88) | 125 (38) | 66 (100) |
| Papilloma | 2 (1)* | 29 (8) | 29 (44) |
| Mammary gland | 126 (49) | 80 (24) | 37 (56) |
| Salivary gland | 148 (57) | 13 (4) | 47 (71) |
| Adrenal medulla | 35 (14) | 0 (0) | 0 (0) |
| Mesenchymal tumors | |||
| Kidney | 123 (47) | 5 (2) | 5 (8)* |
| Bone | 58 (22) | 130 (39) | 51 (77) |
| Subcutaneous connective tissue | 56 (22) | 12 (4) | 25 (38) |
| Vascular endothelium | 12 (5) | 14 (4) | 5 (8)* |
Numbers indicate the number of mice (% in parentheses) with at least one tumor of the designated type. Data for PTA and 315YF were reported previously (16). Both gross and microscopic tumors are reported.
*
Tumors that were detected only or primarily microscopically.