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. 2007 Feb;129(2):161–173. doi: 10.1085/jgp.200609672

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — The peri-TM2 domain of MEC-4, MEC-10, and rat ENaCs. The d position is highlighted in red. In 267 proteins from 36 species in the DEG/ENaC superfamily, the d position is occupied by S > A > G > N in descending order of frequency (Bateman et al., 2004). Residues n after the d position are labeled d + n as referenced in the text. Residue d+7 is indicated with *; mutations at this position in ENaC decrease amiloride K_i' by ∼1,000-fold (Schild et al., 1997).