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. 2007 Feb;129(2):161–173. doi: 10.1085/jgp.200609672

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — Steady-state open probability, P _o (A), single-channel conductance, γ (B), and estimated channel number, N (C), as a function of side-chain volume. Microscopic parameters, P _o and γ, were determined from outside-out patches containing one to two channels. The square root of the probability of not being closed was used as an estimate of P _o for two-channel patches. N was estimated as described in the Results. The data are summarized in Table II. One-way ANOVAs for P _o, γ, and N were as follows: F(5,46) = 8.354, P = 1.11e-05; F(5,46) = 6.791, P = 8.12e-05; and F(5, 97) = 12.94, P = 1.2e-09. Pairwise Dunnet's test with respect to wild-type: *, P < 0.01.