TABLE I.
Relative Permeability for A713X Homomeric Channels
| Isoform | P Li | P K | P Cs | P NMDG |
|---|---|---|---|---|
| A713wt | 1.30 ± 0.04 (5) | 0.24 ± 0.02 (5) | 0.14 ± 0.01 (5) | 0.20 ± 0.02 (5) |
| A713G | 1.45 ± 0.07 (6) | 0.27 ± 0.07 (6) | 0.19 ± 0.08 (5) | 0.09 ± 0.03 (6) |
| A713C | 1.19 ± 0.02 (5) | 0.34 ± 0.07 (5) | 0.19 ± 0.03 (5) | 0.12 ± 0.02 (5) |
| A713Tb | 1.44 ± 0.04 (19) | 0.17 ± 0.02 (21) | 0.044 ± 0.003 (14) | 0.0140 ± 0.0009 (14) |
| A713D | 1.66 ± 0.04 (4)a | 0.26 ± 0.02 (5) | 0.12 ± 0.03 (5) | 0.06 ± 0.01 (5)a |
| A713V | 1.54 ± 0.08 (5) | 0.17 ± 0.02 (5) | 0.04 ± 0.01 (5) | 0.10 ± 0.04 (5) |
Ionic permeability relative to that for Na+ (P X/P Na) was measured for indicated isoforms in two-electrode voltage clamp. Values are Px/PNa and are expressed as mean ± SEM (n). One-way ANOVA for Px/PNa: PLi, F(5,38) = 5.852, P = 0.0004; PK, F(5,40) = 2.966, P = 0.0.0227; PCs, F(5,33) = 3.738; P = 0.0086; PNMDG, F(5,39) = 5.688; P = 0.0.0049.
a
P < 0.01; pairwise Dunnet's test with respect to wild type.
b
Data for A713T are from Goodman et al. (2002).