TABLE II.
10-State | Cooperativity | Dimer-of-dimers | |
---|---|---|---|
χ2 | 16.6 | 17.0 | 16.9 |
Kab [ms−1] | 0.0157 | 0.016 | 0.0076 |
Zab [e0] | 0.60 | 0.60 | 0.625 |
Vab [mV] | −78.2 | −78.4 | −78.4 |
c | N/A | 1.0 | N/A |
γ [ms−1] | 0.40 | 0.29 | 0.27 |
δ [ms−1] | 0.40 | 0.32 | 1.0 |
f | 1.57 | 1.55 | 1.53 |
The only voltage-dependent transitions in the models are the rates determining the S4 movement: α = Kab exp(−Zab(V − Vab)/kT) and β = Kab exp(+Zab(V − Vab)/kT). The other rates are all voltage independent.