Table 4. Cytokine and chemokine secretion induced in human DCs by MV-EDIII and MV-EDIII-ectoM.
| MV-EDIII | MV-EDIII-ectoM | |
| IL-1β | - | - |
| IL2 | - | - |
| IL5 | - | - |
| IL10 | - | - |
| INFγ | - | - |
| Eotaxin | - | - |
| IL7 | + | + |
| IL8 | ++ | ++ |
| IL12p40-70 | + | + |
| IL15 | + | + |
| IL17 | + | + |
| IL1-RA | + | +++ |
| IL2R | + | ++ |
| IL4 | + | +++ |
| IL6 | + | +++ |
| TNFα | + | ++ |
| INFα | + | +++ |
| MCP-1 | + | +++ |
| MIG | + | ++ |
| MIP-1α | + | +++ |
| MIP-1β | + | +++ |
| IP10 | + | ++ |
| RANTES | + | +++ |
Cytokine/chemokine production determined by multiplex assay in supernatants of human DCs incubated in presence of MV-EDIII or MV-EDIII-ectoM (16h incubation). Results are from four independent experiments performed with four different donors. Production levels are indicated as :
(-) basal production by mock-treated DCs
(+) less than twofold increase compared to mock-treated DCs
(++) more than threefold increase compared to mock-treated DCs
(+++) more than fourfold increase compared to mock-treated DCs