Table 1.

Mice vaccinated with DCs loaded with Hsp60sp but not Qdm are significantly protected from the subsequent induction of EAE

Group	Incidence, n (%)	Severity	Mean days
			Onset	Maximum duration
Control	15/16 (94)	2.6 ± 0.63	25 ± 3.6	21 ± 3.2
DC w/Hsp60sp	4/18 (22)	0.6 ± 0.66	53 ± 7.9	3 ± 2.9
DC w/Qdm	13/16 (81)	2.3 ± 0.87	32 ± 8.8	17 ± 4.4
CD8−/DC w/Hsp60sp	10/16 (63)	2.1 ± 0.59	32 ± 2.6	16 ± 1.6

Unless indicated otherwise, values are means ± SD. Control, mice induced to develop EAE without vaccination; DC w/Hsp60sp, mice injected with DCs loaded with Hsp60sp peptide before EAE induction; DC w/Qdm, mice injected with DCs loaded with Qdm peptide before EAE induction; CD8⁻/DC w/Hsp60sp, mice depleted of CD8⁺ T cells by injection of anti-CD8 mAb 53-6.72, 1 week after DC vaccination and 3 days before EAE induction. The data in Table 1 summarize four separate experiments shown in SI Table 5.