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Sequence homology between human 8-oxoG-DNA glycosylase and S. cerevisiae OGG1. Amino acid sequences were aligned by the pileup and bestfit programs in the Genetics Computer Group package (Version 7; ref. 20). Amino acids identical in both sequences are boxed. The position of the possible helix–hairpin–helix motif is indicated. The Lys and Asp residues that have been associated with dual DNA glycosylase/AP lyase activity (13) are shown with an arrow and a circle, respectively.
