Table 1.
Correction of γ-radiation-induced G2-phase chromosome aberrations in A-T cells by using full-length ATM cDNA cloned into the inducible vector pMAT1
| Cell line | Aberrations, no.
|
No. ICA/ metaphase | ||
|---|---|---|---|---|
| sb | cb | Int | ||
| C3ABR | 57 | 0 | 0 | 1.14 |
| AT1ABR | 145 | 0 | 1 | 2.92 |
| AT1ABR + pMAT1 | 150 | 0 | 0 | 3.00 |
| AT1ABR + pMAT1 (induced) | 62 | 2 | 0 | 1.24 |
| AT3ABR | 140 | 1 | 2 | 2.86 |
| AT3ABR + pMAT1 | 144 | 0 | 0 | 2.88 |
| AT3ABR + pMAT1 (induced) | 58 | 1 | 0 | 1.18 |
sb, Chromatid breaks; cb, chromosome breaks; Int, interchanges; ICA, induced chromosome aberrations. Fifty metaphases were analyzed for each sample after exposure to 1 Gy of radiation. AT1ABR and AT3ABR are untransfected cells. Data for ICA are the mean.