Figure 1.

The repertoire of mouse T cells in DR(α*0101,β*0401) transgenic mice. FACS analyses of peripheral blood lymphocytes from HLA-transgenic mice of different genetic background. Cells were stained using mouse CD4, hCD4, and human DR-specific reagents in standard protocols. FITC, fluorescein isothiocyanate; PE, phycoerythrin. (Upper Left) CD4⁺ T cell levels of progeny of DBA/1J mice backcrossed once with I-Aβ^0/0 mice (27% CD4⁺ T cells). (Upper Right) Analysis for a DR0401 mouse without hCD4 on an I-Aβ^0/0 background (3.8% CD4⁺ T cells). (Lower Left and Right) Heterozygous (13.3% CD4⁺ T cells) and homozygous (31.1% CD4⁺ T cells) HLA-DR, hCD4 mice, respectively. The DR4 and hCD4 are part of a single transgene in the C-line mice.