Figure 4.

Summary of identified immunodominant epitopes of GAD65. Boxed sequences represent mapped immunogenic sequences. Thick-lined boxes correspond to immunodominant regions; thin-lined boxes correspond to single-hybridoma-recognized regions. The PEVKEK sequence refers to the area of homology between GAD65 and Coxsackie viral sequence. The black underlining shows DR0401 peptide binding motif sequences (thin line, permissive motifs; thick line, strong motifs) and gray arrowed underlining indicates DR0405 sequences (thin line, permissive motifs; thick line, strong motifs) as predicted using pmotif software and a motif from ref. 17.