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. Author manuscript; available in PMC: 2008 Dec 6.
Published in final edited form as: Neuron. 2007 Dec 6;56(5):851–865. doi: 10.1016/j.neuron.2007.10.021

Figure 5.

Figure 5

GABAergic synaptic transmission also occurred after treatment with tetanus toxin, and was blocked by GAT-1 antagonists. A) IPSC in a neuron pretreated with 10 μg/ml tetanus toxin (27 hours) and vigabatrin (100 μM; 100 hours). The IPSC was blocked by bicuculline (50 μM) and by SKF-89976a (40 μM). Recording was made in Ringer with 2 mM Ca++. B) IPSC in a neuron pretreated with 5 μg/ml tetanus toxin (30 hours) and vigabatrin (100 μM; 124 hours). The IPSC was blocked by SKF-89976a (40 μM) while recording in Ringer with 2 mM Ca++. IPSCs could also be elicited from this neuron in high Mg++/low Ca++ Ringer (last trace). Bars - presynaptic stimulation.