Skip to main content
. Author manuscript; available in PMC: 2008 Dec 6.
Published in final edited form as: Neuron. 2007 Dec 6;56(5):851–865. doi: 10.1016/j.neuron.2007.10.021

Figure 8.

Figure 8

Theoretical dependence of ambient [GABA] on membrane potential and cytosolic [GABA]. Shown are calculations of ambient [GABA] when GAT-1 is at equilibrium (i.e. driving force = 0). At a membrane potential of −60 mV, there will be no net transport of GABA when ambient [GABA] is between 0.04 μM and 0.3 μM for cytosolic [GABA] between 0.5 mM and 4 mM. These levels of ambient GABA span a range that would induce tonic inhibition of neurons expressing high affinity GABAA receptors. Calculations were made assuming intracellular and extracellular [Na+] and [Cl−] of 150, 15, 135 and 10 mM, respectively.