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. 1999 Jul 26;146(2):493–500. doi: 10.1083/jcb.146.2.493

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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3D reconstructions of the control RyR1 displayed in different orientations to illustrate specific features. (a) Likely site of attachment of IpTx_a to RyR1. The difference map was displayed at a higher threshold (in violet) to determine the region of higher rigidity. This region remains connected to the RyR1 structure at one location, suggesting that this is the attachment site. (b) The dashed lines indicate bridges of mass connecting domain 3 and the transmembrane assembly. The asterisk indicates the likely site of attachment of IpTx_a.