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. 2000 Jan 10;148(1):159–172. doi: 10.1083/jcb.148.1.159

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Ultrastructural localization of PSD-95 at synaptic and nonsynaptic sites. The silver-intensified colloidal gold (SIG) method was used for electron micrographic immunolabeling of PSD-95 in visual cortex. (A) Gold particles are associated with the PSD within a spine (arrowhead in Sp1) that opposes an unlabeled terminal, T. Two other spines (Sp2 and Sp3) are without SIG immunolabeling. Within the dendritic shaft (Sh), immunoreactivity is associated with the plasma membrane (curved arrow) and elsewhere. (B) Within a dendritic spine (Sp) of an asymmetric synapse, PSD-95 (dark arrow) is associated with the spine apparatus (three fine arrows). The open arrow points to the unlabeled postsynaptic density. In a dendritic shaft below (Sh), SIG label (curved arrow) is associated with a complex of smooth ER (four fine arrows). Another shaft, to the left of Sp, exhibits immunoreactivity in the cytoplasm, as is shown in A. Bar, 500 nm.